The effect of DNA methylation on the transcriptional activity of the hamster adenine
phosphoribosyltransferase (aprt) and the herpes thymidine kinase (tk) genes has been …

The effect of DNA methylation on the expression of the hamster adenine
phosphoribosyltransferase (aprt) gene in mouse cells has been examined. This gene was …

There are at least two systems in which inhibitory effects of DNA modification on DNA-
protein interactions have been unambiguously demonstrated.(i) At sequences specifically …

The above experiments support a relatively simple model to explain the role of DNA
methylation in vivo. Most tissue-specific genes are methylated. The methyl groups may …

DNA methylation is commonly associated with gene silencing, and a link between histone
deacetylation and DNA methylation has been established. However, the transcriptional …

The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …

Three basic approaches have been employed in the study of the effect of DNA methylation
of particular genes on their expression. One approach uses chemicals that cause …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …

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Cytosine methylation within CpG dinucleotides has been implicated in the regulation of
gene expression in vertebrates and, in some cases, has been shown to be causative in …