Although the first observations of the inhibitory effect of methylation on gene activity were
made almost a decade ago, the mechanism by which methyl groups affect transcription is …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …

The establishment of de novo patterns of DNA methylation in mammalian genomes is
characterized by the gradual spreading of methylation, which has been documented to …

DNA (cytosine-5)-methyltransferases (EC 2.1. 1.37) maintain patterns of methylated cytosine
residues in the mammalian genome; faithful maintenance of methylation patterns is required …

Methylation of cytosine in the DNA inhibits the transcription by RNA polymerase II in higher
eukaryotes, but has no influence on RNA polymerase I transcription. The effect on RNA …

In this report we test the hypothesis that a cis-acting methylation center can induce
epigenetic gene inactivation. The cis-acting element used is an 838-base pair fragment that …

DNA methylation: A molecular lock: Current Biology Skip to Main Content Advertisement Current
Biology This journal offers authors two options (open access or subscription) to publish research …

CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …

The effect of DNA methylation at specific promoter sites on gene expression was tested by
using a sensitive and quantitative assay system. The plasmid pSVO CAT contains the …

The genomic DNAs of vertebrates and many invertebrates contain 5-methylcytosine (5-
meCyt) as the only modified base (Table 10.1). Considerable interest in DNA methylation …