It has become clear over the last few years that DNA methylation is essential for normal
embryonic development and that alterations in DNA methylation are very common in cancer …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

DNA methylation is a mechanism for changing the base sequence of DNA without altering
its coding function. As a heritable, yet reversible, epigenetic change, it has the potential of …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

Aberrant DNA methylation is known as an important cause of human cancers, along with
mutations. Although aberrant methylation was initially speculated to be similar to mutations …

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …