Genome-wide demethylation has been suggested to be a step in carcinogenesis. Evidence
for this notion comes from the frequently observed global DNA hypomethylation in tumour …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

Changes in the genome which result in cancer promotion remain a complex interplay of
aberrant methylation in the setting of a multitude of epigenetic changes. The events leading …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Cancer cells and tissues exhibit genome wide hypomethylation and regional
hypermethylation. CpG-methylation of DNA (Me CpG-DNA) is defined as the formation of a …

DNA methylation and chromatin structure patterns are tightly linked components of the
epigenome, which regulate gene expression programming. Two contradictory changes in …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …

Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …