Melatonin could act on immune system by regulating cytokine production of
immunocompetent cells. The hormone enhances IL-2, IFN-γ and IL-6 production by cultured …

Human lymphocytes have recently been described as an important physiological source of
melatonin (N‐acetyl‐5‐methoxytryptamine), which could be involved in the regulation of the …

Since melatonin was first isolated in 1958 up to the last few years, this substance was
considered a hormone exclusive to the pineal gland. Although melatonin has lately been …

This paper shows that melatonin is able to activate human Th1 lymphocytes by increasing
the production of IL-2 and IFN-gamma in vitro. Th2 cells appear not to be affected by …

Our preceding results have shown that melatonin administration to normal and
immunodepressed mice increases significantly the antibody response. We also found that …

Melatonin is hypothesized to play a role in neuroimmunomodulation. This study investigated
the in vitro effects of melatonin (10− 12–10− 6 M) on human peripheral blood mononuclear …

It has been historically assumed that the pineal gland is the major source of melatonin (N‐
acetyl‐5‐methoxytryptamine) in vertebrates. Melatonin plays a central role in fine‐tuning …

Growing evidence has supported the conclusion that melatonin, a pineal hormone,
modulates the immune function. In our previous study, we evaluated in vivo the potential role …

Earlier studies have shown that the pineal hormone melatonin activates human monocytes.
It is reported here that melatonin induces the secretion of IL-1, IL-6, and TNF in fresh and 1 …

Melatonin was initially extracted from the pineal gland and was thought to be produced
exclusively by this organ. Subsequently it was shown that melatonin is also produced in …