DNA methylation is a dynamic epigenetic modification found in most eukaryotic genomes. It
is known to lead to a high CpG to TpG mutation rate. However, the relationship between the …

Background DNA methylation, which mainly occurs at CpG dinucleotides, is a dynamic
epigenetic regulation mechanism in most eukaryotic genomes. It is already known that …

Background A major goal in the study of molecular evolution is to unravel the mechanisms
that induce variation in the germ line mutation rate and in the genome-wide mutation profile …

Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …

The epigenome consists of chemical changes in DNA and chromatin that without modifying
the DNA sequence modulate gene expression and cellular phenotype. The epigenome is …

Dynamic changes in DNA methylation at the gene-specific and genome-wide level occur
during mammalian germ-cell development. However, the details of how the methylation …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

Inter-individual and regional variability in recombination rates cannot be fully explained by
the DNA sequence itself. Epigenetic mechanisms might be one additional factor affecting …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

DNA methylation is an important epigenetic modification involved in many biological
processes and diseases. Many studies have mapped DNA methylation changes associated …