Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease
(ARPKD). Pkhd1 encodes fibrocystin/polyductin (FPC), a ciliary type I membrane protein of …

Fibrocystin/polyductin (FPC), the gene product of PKHD1, is responsible for autosomal
recessive polycystic kidney disease (ARPKD). This disease is characterized by …

Autosomal recessive polycystic kidney disease is caused by mutations in PKHD1, which
encodes the membrane-associated receptor-like protein fibrocystin/polyductin (FPC). FPC …

Autosomal recessive polycystic kidney disease (ARPKD) is a significant hereditary renal
disease occurring in infancy and childhood, which presents with greatly enlarged echogenic …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and …

Integrin-associated focal adhesion complex formation and turnover plays an essential role in
directing interactions between epithelial cells and the extracellular matrix during …

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder
characterized by abnormal cellular proliferation, cyst fluid accumulation, extracellular matrix …

Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene
mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the disease is …

Recent evidence suggests that fibrocystin/polyductin (FPC), polycystin-1 (PC1), and
polycystin-2 (PC2) are all localized at the plasma membrane and the primary cilium, where …