Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may
lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and …

The pathogenesis and natural history of intracranial aneurysm (IA) remains poorly
understood. To this end, animal models with induced cerebral vessel lesions mimicking …

Animal models make an important contribution to our basic understanding of the
pathobiology of human brain aneurysms, are indispensable in testing novel treatment …

Intracranial aneurysms (IAs) are rare vascular lesions that are more frequently found in
women. The pathophysiology behind the formation and growth of IAs is complex. Hence, to …

Arterial aneurysms continue to provide a clinical challenge for neurosurgeons and vascular
surgeons. Many different animal models have been developed in which the pathogenesis …

Subarachnoid hemorrhage secondary to rupture of an intracranial aneurysm is a highly
lethal medical condition. Current management strategies for unruptured intracranial …

Intracranial aneurysms can be induced by a single stereotaxic injection of elastase into the
cerebrospinal fluid at the right basal cistern in hypertensive mice. This mouse model …

Background. Most available large animal extracranial aneurysm models feature healthy non-
degenerated aneurysm pouches with stable long-term follow-ups and extensive healing …

Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage
and is associated with significant morbidity and death. Up to 50% of individuals do not …

We have developed a mouse model of intracranial aneurysm that recapitulates key features
of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs …