Pharmacological treatment of abdominal aortic aneurysm

T Miyake, R Morishita - Cardiovascular research, 2009 - academic.oup.com
Abdominal aortic aneurysm (AAA) is a common degenerative condition with high mortality in
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …

Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …

Reflections on the pathogenesis of abdominal aortic aneurysms

RW Thompson - Cardiovascular Surgery, 2002 - Elsevier
The care of patients with abdominal aortic aneurysms (AAAs) has served as a benchmark of
progress in vascular surgery for more than 50 years. Beginning with the introduction of …

Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy

H Aoki, K Yoshimura, M Matsuzaki - Journal of Molecular Medicine, 2007 - Springer
Abdominal aortic aneurysm (AAA) is a common disease that causes progressive expansion
and rupture of the aorta with high mortality. There is a large and unmet need for nonsurgical …

Molecular imaging of experimental abdominal aortic aneurysms

AK Ramaswamy, M Hamilton, RV Joshi… - The Scientific World …, 2013 - Wiley Online Library
Current laboratory research in the field of abdominal aortic aneurysm (AAA) disease often
utilizes small animal experimental models induced by genetic manipulation or chemical …

The murine angiotensin II-induced abdominal aortic aneurysm model: rupture risk and inflammatory progression patterns

RY Cao, T Amand, MD Ford, U Piomelli… - Frontiers in …, 2010 - frontiersin.org
An abdominal aortic aneurysm (AAA) is an enlargement of the greatest artery in the body
defined as an increase in diameter of 1.5-fold. AAAs are common in the elderly population …

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies

FM Davis, DL Rateri, A Daugherty - Heart, 2014 - heart.bmj.com
Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally
asymptomatic, progression of aneurysms is associated with the devastating consequences …

Pathogenesis of abdominal aortic aneurysm: an update and look toward the future

JJ Grange, V Davis, BT Baxter - Cardiovascular surgery, 1997 - Elsevier
To date, aneurysm research has been primarily descriptive, reiterating the complex nature of
the disease process. Enhanced by the convergence of matrix biochemistry, cell biology and …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem

RW Thompson - Current opinion in cardiology, 1996 - journals.lww.com
Abdominal aortic aneurysms (AAAs) are an increasingly common and potentially lethal
condition. Surgical repair of AAA is now yet performed quite safely, yet ruptured AAAs still …