Reflections on the pathogenesis of abdominal aortic aneurysms
RW Thompson - Cardiovascular Surgery, 2002 - journals.sagepub.com
The care of patients with abdominal aortic aneurysms (AAAs) has served as a benchmark of
progress in vascular surgery for more than 50 years. Beginning with the introduction of …
progress in vascular surgery for more than 50 years. Beginning with the introduction of …
Principles of genetic murine models for cardiac disease
KE Yutzey, J Robbins - Circulation, 2007 - Am Heart Assoc
It was only≈ 15 years ago that methodologies evolved to the point where we began to
manipulate the genetic apparatus of the mouse such that proteins of the investigator's choice …
manipulate the genetic apparatus of the mouse such that proteins of the investigator's choice …
Animal models of atherosclerosis
YT Lee, V Laxton, HY Lin, YWF Chan… - Biomedical …, 2017 - spandidos-publications.com
Atherosclerosis is a significant cause of morbidity and mortality globally. Many animal
models have been developed to study atherosclerosis, and permit experimental conditions …
models have been developed to study atherosclerosis, and permit experimental conditions …
Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond
50% of its normal diameter, is a common and potentially life-threatening vascular disease …
50% of its normal diameter, is a common and potentially life-threatening vascular disease …
Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms
TW Chang, ASA Gracon… - American Journal of …, 2015 - journals.physiology.org
The abdominal aortic aneurysm (AAA) is a disease process that carries significant morbidity
and mortality in the absence of early identification and treatment. While current management …
and mortality in the absence of early identification and treatment. While current management …
A novel mechanism underlying inflammatory smooth muscle phenotype in abdominal aortic aneurysm
Rationale: Abdominal aortic aneurysm (AAA) is a permanent and localized dilatation of
abdominal aorta with potentially fatal consequence of aortic rupture. No effective …
abdominal aorta with potentially fatal consequence of aortic rupture. No effective …
Parallel murine and human aortic wall genomics reveals metabolic reprogramming as key driver of abdominal aortic aneurysm progression
G Gäbel, BH Northoff, A Balboa… - Journal of the …, 2021 - Am Heart Assoc
Background While numerous interventions effectively interfered with abdominal aortic
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
Modulation of immune‐inflammatory responses in abdominal aortic aneurysm: Emerging molecular targets
H Li, S Bai, Q Ao, X Wang, X Tian, X Li… - Journal of …, 2018 - Wiley Online Library
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …
degenerative process of the abdominal aorta. In this process, inflammatory responses and …
Dysregulations of key regulators of angiogenesis and inflammation in abdominal aortic aneurysm
D Zalewski, P Chmiel, P Kołodziej, G Borowski… - International Journal of …, 2023 - mdpi.com
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
Pathophysiology of abdominal aortic aneurysms: insights from the elastase‐induced model in mice with different genetic backgrounds
RW Thompson, JA Curci, TL Ennis… - Annals of the New …, 2006 - Wiley Online Library
Abdominal aortic aneurysms (AAAs) represent a complex degenerative disorder involving
chronic aortic wall inflammation and destructive remodeling of structural connective tissue …
chronic aortic wall inflammation and destructive remodeling of structural connective tissue …