Objectives: Abdominal aortic aneurysm (AAA), a dilatation of the infrarenal aorta, typically
affects males> 65 years. The pathobiological mechanisms of human AAA are poorly …

Cardiovascular disease is the main cause of death in the world. The underlying cause in
most cases is atherosclerosis, which is in part a chronic inflammatory disease. Experimental …

Due to the biological complexity of the cardiovascular system, the animal model is an urgent
pre-clinical need to advance our knowledge of cardiovascular disease and to explore new …

The mouse has become the preferred species for genetic manipulation aimed at creating
and studying models for human disease. Although mice are highly resistant to …

Abdominal aortic aneurysm (AAA) is a common and frequently lethal disease of older
Americans. No medical therapy has been proven effective in retarding progression of small …

Age is a major risk factor for abdominal aortic aneurysm (AAA), for which treatment options
are limited to surgical intervention for large AAA and watchful waiting for small aneurysms …

The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths
worldwide each year. However, there are currently no effective drug therapies to prevent …

Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which
the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a …

The patient with abdominal aortic aneurysm (AAA) commonly is a nondiabetic, white man
with a history of smoking. Moreover, AAA represents a leading cause of death in elderly men …

Abdominal aortic aneurysms (AAAs) are present in 8% of men 60 years of age. 1 The
diagnosis of AAA in many patients is made only after aneurysm rupture, after which mortality …