AAA disease: mechanism, stratification, and treatment
Abdominal aortic aneurysm (AAA) is a common and frequently lethal disease of older
Americans. No medical therapy has been proven effective in retarding progression of small …
Americans. No medical therapy has been proven effective in retarding progression of small …
[HTML][HTML] The role of epigenetic modifications in abdominal aortic aneurysm pathogenesis
K Mangum, K Gallagher, FM Davis - Biomolecules, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity and mortality in the setting of acute rupture. Recently, advances in surgical and …
morbidity and mortality in the setting of acute rupture. Recently, advances in surgical and …
Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm?
B Trachet, L Aslanidou, A Piersigilli… - Cardiovascular …, 2017 - academic.oup.com
Abstract Aims Angiotensin II-infused ApoE-/-mice are a popular mouse model for preclinical
aneurysm research. Here, we provide insight in the often-reported but seldom-explained …
aneurysm research. Here, we provide insight in the often-reported but seldom-explained …
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
Age is a major risk factor for abdominal aortic aneurysm (AAA), for which treatment options
are limited to surgical intervention for large AAA and watchful waiting for small aneurysms …
are limited to surgical intervention for large AAA and watchful waiting for small aneurysms …
[HTML][HTML] Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice
Y Wang, O Sargisson, DT Nguyen, K Parker… - International Journal of …, 2023 - mdpi.com
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths
worldwide each year. However, there are currently no effective drug therapies to prevent …
worldwide each year. However, there are currently no effective drug therapies to prevent …
Novel insight into the pathobiology of abdominal aortic aneurysm and potential future treatment concepts
N Diehm, F Dick, T Schaffner, J Schmidli… - Progress in …, 2007 - Elsevier
The patient with abdominal aortic aneurysm (AAA) commonly is a nondiabetic, white man
with a history of smoking. Moreover, AAA represents a leading cause of death in elderly men …
with a history of smoking. Moreover, AAA represents a leading cause of death in elderly men …
Mechanisms of abdominal aortic aneurysm formation
A Daugherty, LA Cassis - Current atherosclerosis reports, 2002 - Springer
Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which
the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a …
the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a …
Aortic aneurysms: it's all about the stress
FJ Miller Jr - Arteriosclerosis, thrombosis, and vascular biology, 2002 - Am Heart Assoc
Abdominal aortic aneurysms (AAAs) are present in 8% of men 60 years of age. 1 The
diagnosis of AAA in many patients is made only after aneurysm rupture, after which mortality …
diagnosis of AAA in many patients is made only after aneurysm rupture, after which mortality …
[HTML][HTML] Gold nanoparticles that target degraded elastin improve imaging and rupture prediction in an AngII mediated mouse model of abdominal aortic aneurysm
Background: Abdominal aortic aneurysms (AAA) are characterized by a progressive
disruption and weakening of the extracellular matrix (ECM) leading to dilation of the aorta …
disruption and weakening of the extracellular matrix (ECM) leading to dilation of the aorta …
Modeling cardiovascular disease in the zebrafish
The zebrafish possesses a host of advantages that have established it as an excellent
model of vertebrate development. These include ease of genetic manipulation and …
model of vertebrate development. These include ease of genetic manipulation and …