DNA methylation is an epigenetic modification essential for development. The DNA
methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in gastrulating …

DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …

Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

Mutations in the DNA methyltransferase 3A (DNMT3A) gene are the most common cause of
age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most …

DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …

In recent years, an explosion of interest for genome methylation in hematopoietic stem cells
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …