Embryonic stem cells (ESCs) are pluripotent, self‐renewing cells. These cells can be used in
applications such as cell therapy, drug development, disease modeling, and the study of …

Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …

Mammalian development is associated with considerable changes in global DNA
methylation levels at times of genomic reprogramming. Normal DNA methylation is essential …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

From the onset of fertilization, the genome undergoes cell division and differentiation. All of
these developmental transitions and differentiation processes include cell-specific …

In mammals, DNA methylation and hydroxymethylation are specific epigenetic mechanisms
that can contribute to the regulation of gene expression and cellular functions. DNA …

Pluripotent human embryonic stem cells (hESCs) have the distinguishing feature of innate
capacity to allow indefinite self-renewal. This attribute continues until specific constraints or …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

Human embryonic stem cells (hESCs) are a promising model for studying mechanisms
ofregulation of early development and differentiation. OCT4, NANOG, OCT4-related genes …

We report here genome-wide mapping of DNA methylation patterns at proximal promoter
regions in mouse embryonic stem (mES) cells. Most methylated genes are differentiation …