INTRODUCTION: The use of clinical staging models is emerging as a novel and useful
paradigm for diagnosing severe mental disorders. The term" neuroprogression" has been …

Despite significant effort, understanding of the molecular causes and mechanisms of bipolar
disorder (BD) remains a major challenge. Numerous molecular genetic linkage and …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

Clinical studies over the years have provided evidence that monoamine signaling and
hypothalamic-pituitary-adrenal axis disruption are integral to the pathophysiology of bipolar …

Background: Although early interventions in individuals with bipolar disorder may reduce the
associated personal and economic burden, the neurobiologic markers of enhanced risk are …

The authors review existing structural and functional neuroimaging studies of patients with
bipolar disorder and discuss how these investigations enhance our understanding of the …

Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant
morbidity and mortality, with high rates of suicides and medical comorbidities. There is a …

Responding to the explosion of research on the pathophysiology and management of
bipolar disorder, this completely revised Second Edition spans basic mechanisms …

Bipolar affective disorder (BD) is a severe mental illness, characterized by episodes of
mania and depression. With the development of Magnetic Resonance Imaging (MRI) …

Bipolar disorder (BD) is a highly heritable and heterogeneous mental illness whose
manifestations often include impulsive and risk-taking behavior. This particular phenotype …