Background DNA methylomes are extensively reprogrammed during mouse pre-
implantation and early germ cell development. The main feature of this reprogramming is a …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

In mammals, methylation occurs almost exclusively on the CpG dinucleotide in DNA and
shows no preference for sequence context surrounding this target. CpGs are found on many …

Vertebrate genomes are marked by notably high levels of 5-cytosine DNA methylation
(5meC). The clearest function of DNA methylation among members of the subphylum is …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …