Polycystin-1 is a modular membrane protein with a long extracellular N-terminal portion that
bears several ligand-binding domains, 11 transmembrane domains, and a≥ 200 amino …

The primary structure of polycystin predicts a large integral membrane protein with multiple
cell recognition motifs, but its function remains unknown. Insight into polycystin's normal …

Mutations in the PKD1 and PKD2 genes account for 85 and 15% of cases of autosomal
dominant polycystic kidney disease, respectively. Polycystin-2, the product of the PKD2 …

PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was
identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1 …

PKD2 encodes a protein of unknown function that is mutated in 15% of autosomal dominant
polycystic kidney disease (ADPKD) families. We used polyclonal antisera against PKD2 to …

PKD1, the gene that is mutated in approximately 85% of autosomal dominant polycystic
kidney disease (ADPKD) cases in humans, has recently been identified (Eur. PKD …

This short review summarizes some information concerning what is known about matrix
adhesion molecules, focal adhesion proteins, and cell-cell adhesion molecules in normal …

Polycystin-1, the protein defective in a majority of patients with autosomal dominant
polycystic kidney disease, is a ubiquitously expressed multi-span transmembrane protein of …

The functions of the two proteins defective in autosomal dominant polycystic kidney disease,
polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that …

Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of
fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally …