Objective: The aim of this study was to assess the impact of transcriptional induction on
thyroid follicular cell (TFC) differentiation from endodermally matured embryonic stem (ES) …

Objective: The molecular events that lead to human thyroid cell speciation remain
incompletely characterized. It has been shown that overexpression of the regulatory …

The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes,
has led to intense research efforts for their derivation through directed differentiation of …

The derivation of thyrocyte-like cells in culture is of importance in the basic study of early
thyroid embryogenesis and the generation of an unlimited clinical source of thyrocytes for …

Objective: The differentiation program for human thyroid follicular cells (TFCs) relies on the
interplay between sequence-specific transcription factors and transcriptional co-regulators …

Elucidating the molecular mechanisms leading to the induction and specification of thyroid
follicular cells is important for our understanding of thyroid development. To characterize the …

Thyroid differentiation of progenitor cells occurs during embryonic development and in the
adult thyroid gland, and the molecular bases of these complex and finely regulated …

To model the differentiation of thyroid epithelial cells, we examined embryoid bodies derived
from undifferentiated murine embryonic stem cells treated with activin A to induce endoderm …

Background: If methods of differentiating stem cells into thyrocytes can be perfected, they
may provide a ready source of normal thyrocytes for basic research and clinical application …

The replacement of regenerated thyroid follicular cells (TFCs) is a promising therapeutic
strategy for patients with hypothyroidism. Here, we have succeeded in inducing functional …