DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …

DNA methylation is an essential epigenetic modification that plays a key role associated with
the regulation of gene expression during differentiation, but in disease states such as …

One of the most challenging projects in the field of epigenetics is the generation of detailed
functional maps of DNA methylation in different cell and tissue types in normal and disease …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

Methylation of DNA is responsible for gene silencing by establishing heterochromatin
structure that represses transcription, and studies have shown that cytosine methylation of …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …

DNA methylation, a DNA modification by adding methyl group to cytosine, has an important
role in the regulation of gene expression. DNA methylation is known to be associated with …

Aims: To compare the performance of four sequence-based and one microarray methods for
DNA methylation profiling. Methods: DNA from two cell lines were profiled by reduced …

Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of
prostate cancer progression. We mapped the global DNA methylation patterns in select …