Amyloid-β alters the DNA methylation status of cell-fate genes in an Alzheimer's disease model

N Taher, C McKenzie, R Garrett… - Journal of …, 2014 - content.iospress.com
Alzheimer's disease (AD) is characterized by neurofibrillary tangles and extracellular
amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding …

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

R Lardenoije, DLA van den Hove, M Havermans… - Molecular and Cellular …, 2018 - Elsevier
Both aging and Alzheimer's disease (AD) are associated with widespread epigenetic
changes, with most evidence suggesting global hypomethylation in AD. It is, however …

Epigenetic Changes in Alzheimer's Disease: DNA Methylation and Histone Modification

LM De Plano, A Saitta, S Oddo, A Caccamo - Cells, 2024 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and memory loss, imposing a significant burden on affected …

Epigenetics in Alzheimer's disease: a focus on DNA modifications

N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …

[PDF][PDF] DNA methylation alterations in Alzheimer's disease

AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …

Epigenetic modifications in Alzheimer's disease: cause or effect?

I Piaceri, B Raspanti, A Tedde… - Journal of …, 2014 - journals.sagepub.com
Alzheimer's disease (AD) is a multifactorial disorder induced by a combination of genetic
and environmental factors, and epigenetic modifications could be the key to understand the …

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis

M Altuna, A Urdánoz-Casado… - Clinical …, 2019 - Springer
Background Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a
challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD …