Cryptococcus neoformans is a major etiological agent of fungal meningoencephalitis. The
outcome of cryptococcosis depends on the complex interactions between the pathogenic …

Inteins, self-splicing protein elements, interrupt genes and proteins in many microbes,
including the human pathogen Mycobacterium tuberculosis. Using conserved catalytic …

The fungal pathogen Cryptococcus neoformans poses a major threat to
immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV) …

Elevation of arginase enzyme activity in the lung contributes to the pathogenesis of various
chronic inflammatory diseases and infections. Inhibition of arginase expression and activity …

Cryptococcus neoformans is an opportunistic fungal pathogen that threatens individuals with
impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines …

Cyclosporine (CsA) is an immunosuppressive and antimicrobial drug which, in complex with
cyclophilin A, inhibits the protein phosphatase calcineurin. We recently found that …

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …

The immunosuppressant FK506 (tacrolimus) is an antifungal natural product macrolide that
suppresses the immune system by blocking T-cell activation. In complex with the …

Cryptococcus neoformans is one of the most important human fungal pathogens; however,
no new therapies have been developed in over 50 years. Fungicidal activity is crucially …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
infections of the central nervous system. Existing therapies include amphotericin B …