The mammalian genome is punctuated by CpG islands (CGIs), which differ sharply from the
bulk genome by being rich in G+ C and the dinucleotide CpG. CGIs often include …

CpG, 5′-C-phosphate-G-3′, islands (CGIs) have long been known for their association
with enhancers, silencers, and promoters, and for their epigenetic signatures. They are …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides,. Most human gene promoters are …

One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more
than two-thirds of genes, whereas TATA boxes are only present at a minority of promoters …

CpG islands (CGIs) are commonly used as genomic markers to study the patterns and
regulatory consequences of DNA methylation. Interestingly, recent studies reveal a …

CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with∼
80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with …

The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

The primary target for DNA methylation in mammalian genomes is cytosine in the
dinucleotide CpG. High densities of CpG dinucleotides are found in CpG islands, but …