Simultaneous profiling of transcriptome and DNA methylome from a single cell
Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …
The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …
While its presence near the transcription start site of a gene has been associated with …
Passive and active DNA methylation and the interplay with genetic variation in gene regulation
DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …
dependency on genomic sequence and environment are not fully understood. In this study …
Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution
How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …
affect evolution? These are fundamental questions at the forefront of our evolutionary …
DNA methylation: insights into human evolution
I Hernando-Herraez, R Garcia-Perez, AJ Sharp… - PLoS …, 2015 - journals.plos.org
A fundamental initiative for evolutionary biologists is to understand the molecular basis
underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits …
underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits …
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue-and individual-specific DNA methylation patterns
HM Byun, KD Siegmund, F Pan… - Human molecular …, 2009 - academic.oup.com
DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region
DNA methylation is crucial for gene regulation and maintenance of genomic stability. Rat
has been a key model system in understanding mammalian systemic physiology, however …
has been a key model system in understanding mammalian systemic physiology, however …
Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development
RA Waterland, R Kellermayer… - Human molecular …, 2009 - academic.oup.com
The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …
Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation
Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
many biological processes. However, the mechanism of DNA-methylation-dependent gene …
Gene and transposable element methylation in great tit (Parus major) brain and blood
Background Studies on vertebrate DNA methylomes have revealed a regulatory role of
tissue specific DNA methylation in relation to gene expression. However, it is not well known …
tissue specific DNA methylation in relation to gene expression. However, it is not well known …