We report a novel resource (m ethylation p rofiles of D NA, or mPod) for human genome-
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …

The mammalian genome depends on patterns of methylated cytosines for normal function,
but the relationship between genomic methylation patterns and the underlying sequence is …

Background The predominant model for regulation of gene expression through DNA
methylation is an inverse association in which increased methylation results in decreased …

Epigenetic mechanisms traditionally have been studied in the domains of development and
disease, but they may also play important roles in ecological and evolutionary processes. In …

DNA methylation is a dynamic process through which specific chromatin modifications can
be stably transmitted from parent to daughter cells. A large body of work has suggested that …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …

Patterns of DNA methylation in animal genomes are known to vary from an apparent
absence of modified bases, via methylation of a minor fraction of the genome, to genome …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …

DNA methylation refers to the addition of a methyl group to nucleotides within DNA. As with
other epigenetic endpoints, patterns of DNA methylation are susceptible to alterations due to …