Cyclical DNA methylation of a transcriptionally active promoter
R Métivier, R Gallais, C Tiffoche, C Le Péron… - Nature, 2008 - nature.com
Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …
organization. The epigenome contains additional information that is not brought by DNA …
Transient cyclical methylation of promoter DNA
S Kangaspeska, B Stride, R Métivier… - Nature, 2008 - nature.com
Methylation of CpG dinucleotides is generally associated with epigenetic silencing of
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …
Conserved role of intragenic DNA methylation in regulating alternative promoters
AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.
J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
Repression of transcription from densely methylated genes can be mediated by the methyl‐
CpG binding protein MeCP‐1 (Boyes and Bird, 1991). Here we have investigated the effect …
CpG binding protein MeCP‐1 (Boyes and Bird, 1991). Here we have investigated the effect …
DNA methylation represses transcription in vivo
Z Siegfried, S Eden, M Mendelsohn, X Feng… - Nature …, 1999 - nature.com
DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …
established in the animal through a series of developmental events 1. In the mouse blastula …
DNA methylation: old dog, new tricks?
CG Spruijt, M Vermeulen - Nature structural & molecular biology, 2014 - nature.com
DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
[引用][C] Methylation and gene control
G Felsenfeld, J McGhee - Nature, 1982 - nature.com
ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …
expression? There are already many examples of an inverse correlation between the level …
DNA methylation profiling of human chromosomes 6, 20 and 22
F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
Dependence of transcriptional repression on CpG methylation density
CL Hsieh - Molecular and cellular biology, 1994 - Am Soc Microbiol
CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …
be related to alterations of chromatin structure that are specified by the methylation. The …
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