Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

Methylation of CpG dinucleotides is generally associated with epigenetic silencing of
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …

Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …

Repression of transcription from densely methylated genes can be mediated by the methyl‐
CpG binding protein MeCP‐1 (Boyes and Bird, 1991). Here we have investigated the effect …

DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …