Cyclical DNA methylation of a transcriptionally active promoter

R Métivier, R Gallais, C Tiffoche, C Le Péron… - Nature, 2008 - nature.com
Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

Transient cyclical methylation of promoter DNA

S Kangaspeska, B Stride, R Métivier… - Nature, 2008 - nature.com
Methylation of CpG dinucleotides is generally associated with epigenetic silencing of
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …

Conserved role of intragenic DNA methylation in regulating alternative promoters

AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.

J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
Repression of transcription from densely methylated genes can be mediated by the methyl‐
CpG binding protein MeCP‐1 (Boyes and Bird, 1991). Here we have investigated the effect …

DNA methylation represses transcription in vivo

Z Siegfried, S Eden, M Mendelsohn, X Feng… - Nature …, 1999 - nature.com
DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

DNA methylation: old dog, new tricks?

CG Spruijt, M Vermeulen - Nature structural & molecular biology, 2014 - nature.com
DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

M Weber, I Hellmann, MB Stadler, L Ramos, S Pääbo… - Nature …, 2007 - nature.com
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

[引用][C] Methylation and gene control

G Felsenfeld, J McGhee - Nature, 1982 - nature.com
ARE changes in DNA methylation patterns a cause or an effect of eukaryotic gene
expression? There are already many examples of an inverse correlation between the level …

DNA methylation profiling of human chromosomes 6, 20 and 22

F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

Dependence of transcriptional repression on CpG methylation density

CL Hsieh - Molecular and cellular biology, 1994 - Am Soc Microbiol
CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …