Methylation of cytosines in the CG context (mCG) is the most abundant DNA modification in
vertebrates that plays crucial roles in cellular differentiation and identity. After fertilization …

DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …

Background DNA methylation is an epigenetic modification that is ubiquitous across many
eukaryotes, with variable patterns and functions across taxa. The roles of DNA methylation …

DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …

DNA methylation plays crucial roles during embryonic development. Here we present
MethBank (http://dnamethylome. org), a DNA methylome programming database that …

DNA methylation is a critical epigenetic regulator of development in mammals and social
insects, but its significance in development outside these groups is not understood. Here we …

DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been
shown to be involved the regulation of gene expression and embryo development. However …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …