During embryonic development in mammals, most of the methylated cytosines in the
paternal genome are converted to 5-hydroxymethyldeoxycytidine (hmC), as part of DNA …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Vertebrates have highly methylated genomes at CpG positions, whereas invertebrates have
sparsely methylated genomes. This increase in methylation content is considered a major …

Genomes of invertebrates and vertebrates exhibit highly divergent patterns of DNA
methylation. Invertebrate genomes tend to be sparsely methylated, and DNA methylation is …

Background Studies of DNA methylomes in a wide range of eukaryotes have revealed both
conserved and divergent characteristics of DNA methylation among phylogenetic groups …

DNA methylation is an important epigenetic modification that has been repeatedly implied in
organismal adaptation. However, many previous studies that have linked DNA methylation …

DNA methylation patterns and functions are variable across invertebrate taxa. In order to
provide a better understanding of DNA methylation in the Pacific oyster (Crassostrea gigas) …

Background Multicellular organisms require precise gene regulation during ontogeny, and
epigenetic modifications, such as DNA methylation and histone modification, facilitate this …

DNA methylation and histone modifications are epigenetic marks implicated in the complex
regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and …

Background DNA methylation is one of the most important epigenetic modifications of
eukaryotic genomes and is believed to play integral roles in diverse biological processes …