Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation: A molecular lock Page 1 Dispatch R305 DNA methylation: A molecular lock
Zahava Siegfried and Howard Cedar In mammals, the promoters of expressed genes are …

Understanding the mechanisms involved in the regulation of gene expression in eukaryotic
organisms is one of the major challenges facing the modern molecular biologist. Despite …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

The genomic DNAs of vertebrates and many invertebrates contain 5-methylcytosine (5-
meCyt) as the only modified base (Table 10.1). Considerable interest in DNA methylation …

Abnormal regional increases in DNA methylation, which have potential for causing gene
inactivation and chromosomal instability, are consistently found in immortalized and …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …