The biological significance of 5-methylcytosine was in doubt for many years, but is no
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …

Three basic approaches have been employed in the study of the effect of DNA methylation
of particular genes on their expression. One approach uses chemicals that cause …

The addition of a methyl group to a DNA base is known as DNA methylation. Typically, this
occurs at the location of a cytosine proximal to a guanine base and is catalyzed by enzymes …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

The methylation of DNA helps stabilize chromatin in an inactive configuration and inhibits
gene transcription. This mechanism of gene regulation is involved in essential genetic …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …