This paper tests the hypothesis that expression of the DNA methyltransferase, dnmt1, gene
is regulated by a methylation‐sensitive DNA element. Methylation of DNA is an attractive …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

DNA methylation has come of age. For more than 40 years, it has been known that
eukaryotes tag their DNA by the covalent addition of a methyl group to cytosine residues; …

The steady state level of DNA methyltransferase mRNA is markedly increased as growth-
arrested Balb/c 3T3 cells progress into the S phase of the cell cycle. mRNA abundance is …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

DNA methylation in mammals is highly dynamic during germ cell and preimplantation
development but is relatively static during the development of somatic tissues. 5 …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …