Background How to best triage human papillomavirus (HPV) positive women remains
controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the …

OBJECTIVE: The study was aimed at understanding the complex interactions of genetic and
epigenetic events in expression of HPV16 E6/E7 and progression of cervical carcinoma. For …

The biological activities of the papillomavirus E2 protein in transcription, replication, and
maintenance of the papillomavirus genome rely on the E2 protein's ability to bind that …

Infection with human papillomavirus‐16 (HPV‐16) is the cause of most anogenital
carcinomas. This virus is also detected in about 20% of all head and neck squamous cell …

Cervical neoplasia‐specific biomarkers, eg DNA methylation markers, with high sensitivity
and specificity are urgently needed to improve current population‐based screening on (pre) …

Objective triage strategies are required to prevent unnecessary referrals for colposcopy in
population‐based screening programs using primary high‐risk human papillomavirus …

Recently, DNA methylation analysis of FAM19A4 in cervical scrapes has been shown to
adequately detect high‐grade cervical intraepithelial neoplasia and cervical cancer (≥ …

High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to
cytology for the detection of high-grade dysplasia and cervical cancer particularly in women …

E2 protein binding to the four E2 binding sites (E2BSs) at the long control region of Human
Papillomavirus (HPV) 16/18 genome may exert either transcriptional activation/repression …

Objective Testing for high risk human papillomavirus (HR-HPV) is increasing; however due
to limitations in specificity there remains a need for better triage tests. Research efforts have …