Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a 10-year prospective cohort study
L Dong, L Zhang, SY Hu, RM Feng, XL Zhao… - Clinical …, 2020 - Springer
Background How to best triage human papillomavirus (HPV) positive women remains
controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the …
controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the …
Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression
D Mazumder, RK Singh, S Mitra, S Dutta… - Gynecologic …, 2011 - Elsevier
OBJECTIVE: The study was aimed at understanding the complex interactions of genetic and
epigenetic events in expression of HPV16 E6/E7 and progression of cervical carcinoma. For …
epigenetic events in expression of HPV16 E6/E7 and progression of cervical carcinoma. For …
Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection
K Kim, PA Garner-Hamrick, C Fisher, D Lee… - Journal of …, 2003 - Am Soc Microbiol
The biological activities of the papillomavirus E2 protein in transcription, replication, and
maintenance of the papillomavirus genome rely on the E2 protein's ability to bind that …
maintenance of the papillomavirus genome rely on the E2 protein's ability to bind that …
Human papillomavirus‐16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas
A Balderas‐Loaeza, G Anaya‐Saavedra… - … journal of cancer, 2007 - Wiley Online Library
Infection with human papillomavirus‐16 (HPV‐16) is the cause of most anogenital
carcinomas. This virus is also detected in about 20% of all head and neck squamous cell …
carcinomas. This virus is also detected in about 20% of all head and neck squamous cell …
A four‐gene methylation marker panel as triage test in high‐risk human papillomavirus positive patients
JJH Eijsink, A Lendvai, V Deregowski… - … journal of cancer, 2012 - Wiley Online Library
Cervical neoplasia‐specific biomarkers, eg DNA methylation markers, with high sensitivity
and specificity are urgently needed to improve current population‐based screening on (pre) …
and specificity are urgently needed to improve current population‐based screening on (pre) …
DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort
RW van Leeuwen, A Oštrbenk, M Poljak… - … Journal of Cancer, 2019 - Wiley Online Library
Objective triage strategies are required to prevent unnecessary referrals for colposcopy in
population‐based screening programs using primary high‐risk human papillomavirus …
population‐based screening programs using primary high‐risk human papillomavirus …
Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high‐risk HPV‐positive …
R Luttmer, LMA De Strooper, J Berkhof… - … journal of cancer, 2016 - Wiley Online Library
Recently, DNA methylation analysis of FAM19A4 in cervical scrapes has been shown to
adequately detect high‐grade cervical intraepithelial neoplasia and cervical cancer (≥ …
adequately detect high‐grade cervical intraepithelial neoplasia and cervical cancer (≥ …
A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women
A Hansel, D Steinbach, C Greinke, M Schmitz, J Eiselt… - PloS one, 2014 - journals.plos.org
High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to
cytology for the detection of high-grade dysplasia and cervical cancer particularly in women …
cytology for the detection of high-grade dysplasia and cervical cancer particularly in women …
HPV 16 E2 binding sites 1 and 2 become more methylated than E2 binding site 4 during cervical carcinogenesis
TW Leung, SS Liu, RCY Leung… - Journal of medical …, 2015 - Wiley Online Library
E2 protein binding to the four E2 binding sites (E2BSs) at the long control region of Human
Papillomavirus (HPV) 16/18 genome may exert either transcriptional activation/repression …
Papillomavirus (HPV) 16/18 genome may exert either transcriptional activation/repression …
[HTML][HTML] Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women
N Vasiljević, D Scibior-Bentkowska, AR Brentnall… - Gynecologic …, 2014 - Elsevier
Objective Testing for high risk human papillomavirus (HR-HPV) is increasing; however due
to limitations in specificity there remains a need for better triage tests. Research efforts have …
to limitations in specificity there remains a need for better triage tests. Research efforts have …