Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Heterogeneity in white blood cells has potential to confound DNA methylation measurements
BT Adalsteinsson, H Gudnason, T Aspelund, TB Harris… - 2012 - journals.plos.org
Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues
are ensembles of cells that may each have their own epigenetic profile, and therefore inter …
are ensembles of cells that may each have their own epigenetic profile, and therefore inter …
Methylomics of gene expression in human monocytes
Y Liu, J Ding, LM Reynolds, K Lohman… - Human molecular …, 2013 - academic.oup.com
DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of
gene expression; however, the extent to which methylation of CpG dinucleotides correlates …
gene expression; however, the extent to which methylation of CpG dinucleotides correlates …
Comparison of methods for quantification of global DNA methylation in human cells and tissues
S Lisanti, WAW Omar, B Tomaszewski, S De Prins… - PloS one, 2013 - journals.plos.org
DNA methylation is a key epigenetic modification which, in mammals, occurs mainly at CpG
dinucleotides. Most of the CpG methylation in the genome is found in repetitive regions, rich …
dinucleotides. Most of the CpG methylation in the genome is found in repetitive regions, rich …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique
Genome wide analysis of DNA methylation provides important information in a variety of
diseases, including cancer. Here, we describe a simple method, Digital Restriction Enzyme …
diseases, including cancer. Here, we describe a simple method, Digital Restriction Enzyme …
A human B cell methylome at 100− base pair resolution
Using a methylated-DNA enrichment technique (methylated CpG island recovery assay,
MIRA) in combination with whole-genome tiling arrays, we have characterized by MIRA-chip …
MIRA) in combination with whole-genome tiling arrays, we have characterized by MIRA-chip …
Different measures of “genome-wide” DNA methylation exhibit unique properties in placental and somatic tissues
DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …
is used to assess “global” changes in DNA methylation in studies of human disease and …
Variations in DNA methylation patterns during the cell cycle of HeLa cells
SE Brown, MF Fraga, ICG Weaver, M Berdasco… - Epigenetics, 2007 - Taylor & Francis
DNA methylation has been viewed as a stable component of the epigenome, which is
established during development and fixed thereafter. We show here using nearest neighbor …
established during development and fixed thereafter. We show here using nearest neighbor …
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls
Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …
epigenetic influence on human traits and disease. In addition to influences of age and …
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