Inbred strains of mice exhibit large genetic variations in hepatic 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase activity. A tissue-specific genetic variation between the …

The premise that the intrinsic level of expression of hepatic 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase determines the relative sensitivity to the serum …

The 5'-flanking region of the gene for hamster 3-hydroxy-3-methylglutaryl coenzyme A
reductase (HMG-CoA reductase) is shown to contain promoter sequences that drive …

The mechanisms by which sterols and nonsterols regulate hepatic 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase gene expression was investigated by …

The level of gene expression at which dietary cholesterol exerts feedback regulation on
hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was investigated …

The possibility that potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase may alter the mechanisms by which dietary cholesterol and farnesol regulate this …

Although substantial evidence supports the conclusion that 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase is the major regulatory enzyme in cholesterol …

Revised Manuscript Received October 25, 1993Ū abstract: It has been suggested that the
down-regulation of hepatic HMG-CoA reductase by dietary cholesterol requires modification …

This study addresses whether transcriptional control of the 3-hydroxy-3-methylglutaryl
coenzyme A reductase gene in rat liver plays a role in determining the level of reductase …

A monoclonal antibody directed against 3-hydroxy-3-methylglutaryl Coenzyme A reductase
and a cDNA to reductase mRNA were used to study the subunit structure of the enzyme and …