Glioblastoma multiforme (GBM) is the most aggressive of all brain tumors, with a median
survival of less than 1.5 years. Recently, epigenetic alterations were found to play key roles …

Glioblastoma (GBM) is one of the most aggressive types of cancer and exhibits profound
genetic and epigenetic heterogeneity, making the development of an effective treatment a …

Background Changes in promoter DNA methylation pattern of genes involved in key
biological pathways have been reported in glioblastoma. Genome-wide assessments of …

DNA methylation plays an important role in cancer biology and methylation events are
important prognostic and predictive markers in many tumor types. We have used methylation …

The study of survival outliers of glioblastoma can provide important clues on gliomagenesis
as well as on the ways to alter clinical course of this almost uniformly lethal cancer type …

Objective: To identify a specific hypermethylated molecular biomarker for human malignant
glioblastoma prognosis. Materials and Methods: Genome-wide methylation profiling was …

Glioblastoma multiforme (GBM) is the most common, most invasive, and malignant type of
primary brain tumor with poor prognosis and poor survival rate. Using GSE22891 the …

DNA methylation is an epigenetic change to the genome that impacts gene activities without
modification to the DNA sequence. Alteration in the methylation pattern is a naturally …

In order to find clinically useful prognostic markers for glioma patients' survival, we employed
Monte Carlo Feature Selection and Interdependencies Discovery (MCFS-ID) algorithm on …

Background/Aims: In the current study, we performed an integrated analysis of genome-wide
methylation and gene expression data to find novel prognostic genes for lower-grade …