[HTML][HTML] Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions inde novo methylation
Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
[PDF][PDF] CpG-island methylation in aging and cancer
JP Issa - Current topics in microbiology and immunology, 2000 - researchgate.net
CpG islands are small (0.5–2kb) CpG-rich areas that are commonly found in the promoters
of expressed genes (BIRD 1986). In the early studies that established the concept of CpG …
of expressed genes (BIRD 1986). In the early studies that established the concept of CpG …
[HTML][HTML] DNA motifs associated with aberrant CpG island methylation
Epigenetic silencing involving the aberrant methylation of promoter region CpG islands is
widely recognized as a tumor suppressor silencing mechanism in cancer. However, the …
widely recognized as a tumor suppressor silencing mechanism in cancer. However, the …
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors
G Zardo, MI Tiirikainen, C Hong, A Misra… - Nature …, 2002 - nature.com
Aberrant methylation of CpG islands and genomic deletion are two predominant
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …
mechanisms of gene inactivation in tumorigenesis, but the extent to which they interact is …
Analysis of promoter CpG island hypermethylation in cancer: location, location, location!
IJH Van Vlodrop, HEC Niessen, S Derks… - Clinical cancer …, 2011 - AACR
The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being
identified. This provides novel insights in tumor biology as well as in potential cancer …
identified. This provides novel insights in tumor biology as well as in potential cancer …
CpG island hypermethylation in human astrocytomas
Astrocytomas are common and lethal human brain tumors. We have analyzed the
methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain …
methylation status of over 28,000 CpG islands and 18,000 promoters in normal human brain …
DNA methylation differences associated with tumor tissues identified by genome scanning analysis
Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …
changes associated with known tumor suppressor genes. This may have led to an …
High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
F Antequera, J Boyes, A Bird - Cell, 1990 - cell.com
CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …