To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used
methylated CpG island amplification (MCA) coupled with representational difference …

Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates.
Aberrant methylation of CpG islands in human tumors has been shown to cause …

Cancer has long been known to be a disease caused by alterations in the genetic blueprint
of cells. In the past decade it has become evident that epigenetic processes have a function …

The stomach is one of the organs whose epithelial cells frequently undergo aberrant
methylation of CpG islands. To date, several reports on the methylation of various genes in …

The genome of epithelial tumors is characterized by numerous chromosomal aberrations,
DNA base sequence changes, and epigenetic abnormalities. The epigenome of cancer cells …

Genetic alterations occur during the adenoma‐carcinoma sequence of colon cancer
formation and drive the initiation and progression of colon cancer formation. The aberrant …

To date, several reports on methylation of various genes in gastric cancer (GC) have been
published. However, most of these studies focused on cancer tissues or a single gene only …

DNA methylation patterns in CpG-rich regions of promoter, CpG islands, are concerned in
regulation of gene expression in mammalian cells. Excessive methylation of CpG …

Hypomethylation of the global genome, considered to be composed mainly of repetitive
sequences, is consistently observed in cancers, and aberrant hypo‐and hypermethylation of …

Aberrant methylation of 5′ CpG islands is a key epigenetic event in many human cancers.
A PCR-based technique of methylated CpG island amplification followed by …