Purpose: The goal of this study was to comprehensively identify CpG island methylation
alterations between pancreatic cancers and normal pancreata and their associated gene …

We report that CpG island methylation, an epigenetic modification of DNA known to correlate
closely with silencing of gene transcription, appears in the oestrogen receptor (ER) gene in …

Mammalian CpG islands are key epigenomic elements that were first characterized
experimentally as genomic fractions with low levels of DNA methylation. Currently, CpG …

DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …

Strong evidence exists for a subgroup of tumours, from a variety of tissue types, exhibiting
concordant tumour specific DNA methylation: the “CpG island methylator phenotype”(CIMP) …

Methylation of CpG islands is associated with transcriptional silencing and the formation of
nuclease-resistant chromatin structures enriched in hypoacetylated histones 1, 2, 3. Methyl …

Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …

Epigenetic modifications such as aberrant DNA methylation reshape the gene expression
repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) …

Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic
aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) …

Vertebrate genomic DNA is generally CpG depleted 1, 2, possibly because methylation of
cytosines at 80% of CpG dinucleotides results in their frequent mutation to thymine, and thus …