Oxaliplatin is the only third-generation platinum derivative compound that has found a place
in the routine treatment of colorectal cancer (CRC). The appearance of oxaliplatin, as well as …

Colorectal cancer is one of the leading causes of death from malignant diseases in the
Western world. Worldwide,∼ 50% of patients who present with colorectal cancer will …

For nearly 40 years, the medical treatment of colorectal cancer had been limited to the
fluoropyrimidines until the recent development of irinotecan (CPT-11). In the past decade, a …

Introduction: Oxaliplatin, a second-generation platinum analog, has evolved as one of the
most important therapeutic agents in colorectal cancer (CRC) treatment. It has had a major …

Significant advances in the treatment of colorectal cancer have been observed over the past
several years. With the introduction of oxaliplatin combined with infusional 5-fluorouracil and …

Abstract▴ Oxaliplatin is available in numerous countries for the treatment of metastatic
colorectal cancer (in conjunction with fluoropyrimidine therapy). The activity of oxaliplatin in …

Oxaliplatin (Eloxatin; Sanofi, Gentilly, France), a third-generation platinum compound with a
1, 2-diaminocyclohexane (DACH) carrier ligand, is a recently developed agent with activity …

Oxaliplatin, a platinum compound characterized by a diaminocyclohexane (DACH) platinum
carrier ligand, has proven its efficacy in first-and second-line advanced colorectal cancer …

Oxaliplatin is a platinum compound that inhibits DNA synthesis, primarily by causing
intrastrand cross-links in DNA. Oxaliplatin has a broad spectrum of antineoplastic activity …

OXALIPLATIN IS a third-generation platinum compound with a 1, 2 diaminocyclohexane
carrier ligand. This important difference in the molecule, and hence in the DNA adducts …