DNA methylation dynamics during the mammalian life cycle
JA Hackett, MA Surani - … of the Royal Society B: Biological …, 2013 - royalsocietypublishing.org
DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …
phases of reprogramming and de novo methylation. These events enable the acquisition of …
De novo DNA methylation: a germ cell perspective
SA Smallwood, G Kelsey - Trends in Genetics, 2012 - cell.com
DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …
genome that has widespread influences on gene expression. During germ-cell specification …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
[HTML][HTML] Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells
DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …
reprogramming in the mammalian germ line, including pre-implantation embryos and …
DNA methylation homeostasis in human and mouse development
The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …
development need to be tightly balanced to maintain a physiological equilibrium. Here we …
DNA methylation dynamics in cellular commitment and differentiation
M Suelves, E Carrió, Y Núñez-Álvarez… - Briefings in functional …, 2016 - academic.oup.com
DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
Imprinting and epigenetic changes in the early embryo
JR Weaver, M Susiarjo, MS Bartolomei - Mammalian Genome, 2009 - Springer
Imprinted genes are epigenetically regulated so that only one allele is expressed in a parent-
of-origin-dependent manner. Although they represent a small subset of the mammalian …
of-origin-dependent manner. Although they represent a small subset of the mammalian …
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers
In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …
Emerging concept in DNA methylation: role of transcription factors in shaping DNA methylation patterns
DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …
regulation and development. DNA methylation patterns are established during early …