DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …

The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

Imprinted genes are epigenetically regulated so that only one allele is expressed in a parent-
of-origin-dependent manner. Although they represent a small subset of the mammalian …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …