Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

Genome‐wide DNA demethylation, including the erasure of genome imprints, in primordial
germ cells (PGCs) is a critical first step to creating a totipotent epigenome in the germ line …

Mouse primordial germ cells (PGCs) erase global DNA methylation (5mC) as part of the
comprehensive epigenetic reprogramming that occurs during PGC development. 5mC plays …

DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …

Epigenetic modifications serve as an extension of the information content by which the
underlying genetic code may be interpreted. These modifications mark genomic regions and …

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Erasure and subsequent reinstatement of DNA methylation in the germline, especially at
imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …