Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …

DNA methylation is necessary for the silencing of endogenous retrotransposons and the
maintenance of monoallelic gene expression at imprinted loci and on the X chromosome …

DNA methylation patterns are set up in a relatively fixed programmed manner during normal
embryonic development and are then stably maintained. Using genome-wide analysis, we …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …

In mammals, methylation occurs almost exclusively on the CpG dinucleotide in DNA and
shows no preference for sequence context surrounding this target. CpGs are found on many …

Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …

Recent findings shed light on the coordination of two fundamental, yet mechanistically
opposing, processes in the early mammalian embryo. During the oocyte-to-embryo …

Background DNA methylomes are extensively reprogrammed during mouse pre-
implantation and early germ cell development. The main feature of this reprogramming is a …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …