As a reversible epigenetic modification which can affect gene expression, DNA methylation
has been an attractive candidate for the biochemical mechanism of genomic imprinting …

Abstract Changes in DNA methylation profiles are common features of development and in a
number of human diseases, such as cancer and imprinting disorders like Beckwith …

Genomic imprinting is a special form of epigenetic system that determines the parent-of-
origin-specific, or monoallelic, expression of a small number of genes, termed" imprinted" …

In mammals, the maternal and paternal genomes are both required for normal embryonic
and postnatal development. As a consequence, the majority of genes possess a bi-allelic …

Publisher Summary This chapter presents a methylation mosaic model for mammalian
genome imprinting. This model predicts that the paternally transmitted allele at some loci will …

This review explores the features of imprinted locithat have been uncovered by genetic
experiments in the mouse. Imprinted genes are expressed from one parental allele and …

Genomic Imprinting: Imprinting with and without methylation: Current Biology Skip to Main
Content Advertisement Current Biology This journal offers authors two options (open access or …

A small number of mammalian genes undergo the process of genomic imprinting whereby
the expression level of the alleles of a gene depends upon their parental origin. In the past …

Genomic imprinting is an epigenetic form of gene regulation that entails differential sex-
specific methylation of the alleles of a gene. Such methylation distinguishes male and …

Monoallelic expression in diploid mammalian cells appears to be a widespread
phenomenon, with the most studied examples being X-chromosome inactivation in …