When melatonin gets on your nerves: its beneficial actions in experimental models of stroke
This article summarizes the evidence that endogenously produced and exogenously
administered melatonin reduces the degree of tissue damage and limits the biobehavioral …
administered melatonin reduces the degree of tissue damage and limits the biobehavioral …
Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke
This review summarizes the numerous reports that have documented the neuroprotective
actions of melatonin in experimental models of ischemia/reperfusion injury (stroke). In these …
actions of melatonin in experimental models of ischemia/reperfusion injury (stroke). In these …
Ischemic brain injury: New insights on the protective role of melatonin
Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …
of people worldwide. The plethora of physiopathological events associated with brain …
The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion
RTF Cheung - Journal of pineal research, 2003 - Wiley Online Library
The brain is highly susceptible to focal or global ischemia. Unless ischemia is promptly
reversed, reperfusion produces further cerebral damage. Acute thrombolysis or …
reversed, reperfusion produces further cerebral damage. Acute thrombolysis or …
Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages
HW Lin, EJ Lee - Neuropsychiatric disease and treatment, 2009 - Taylor & Francis
Melatonin (n-acetyl-5-methoxy-tryptamine), a naturally occurring indole produced mainly by
the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second …
the pineal gland, is a well known antioxidant. Stroke (cerebral ischemia) is the second …
Melatonin and ischemia–reperfusion injury of the brain
M Cervantes, G Moralí… - Journal of pineal …, 2008 - Wiley Online Library
This review summarizes the reports that have documented the neuroprotective effects of
melatonin against ischemia/reperfusion brain injury. The studies were carried out on several …
melatonin against ischemia/reperfusion brain injury. The studies were carried out on several …
Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral …
Melatonin is a potent antioxidant with neuroprotective activity in animal models of ischemic
stroke, which based on its lack of serious toxicity has raised hopes that it might be used for …
stroke, which based on its lack of serious toxicity has raised hopes that it might be used for …
Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia
Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion,
which was attributed to loss of antioxidant action of melatonin. However, melatonin also has …
which was attributed to loss of antioxidant action of melatonin. However, melatonin also has …
Signal transduction pathways involved in melatonin‐induced neuroprotection after focal cerebral ischemia in mice
Because of its favorable action profile in humans, melatonin is a particularly interesting
candidate as a neuroprotectant in acute ischemic stroke. Until now, the signaling …
candidate as a neuroprotectant in acute ischemic stroke. Until now, the signaling …
Protective effects of melatonin in ischemic brain injury
S Cuzzocrea, G Costantino, E Gitto… - Journal of pineal …, 2000 - Wiley Online Library
Recent studies have demonstrated that melatonin is a scavenger of oxyradicals and
peroxynitrite and an inhibitor of nitric oxide (NO) production. NO, peroxynitrite (formed from …
peroxynitrite and an inhibitor of nitric oxide (NO) production. NO, peroxynitrite (formed from …