Background Midazolam, a benzodiazepine, is finding expanded use in neonatal intensive
care units. We studied the pharmacokinetics and metabolism of midazolam after a single …

Aims To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm
infants. Methods After an oral dose (0.1 mg kg− 1), blood was drawn up to 24 h after …

Objective To describe the pharmacokinetics of midazolam, a water‐soluble benzodiazepine
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …

Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …

Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …

Although midazolam is a frequently used sedative in neonatal intensive care units, its use in
preterm neonates has been off‐label. Recently, a new dosing advice for midazolam for …

Objective The aim of this study was to evaluate the pharmacodynamics and safety of
midazolam after intravenous infusion or oral administration in preterm infants. Methods] …

To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of
midazolam in preterm neonates, a physiological population pharmacokinetic model was …

Background Midazolam is used widely as a sedative to facilitate mechanical ventilation. This
prospective study investigated the population pharmacokinetics of midazolam in very …

A simple, selective high‐performance liquid chromatographic method with ultraviolet
detection at 220nm is described for quantitation of midazolam and its primary metabolite 1 …