Reversible covalent histone modifications are known to influence spatiotemporal patterns of
gene transcription during development. Here I review recent advances in the development …

The complex processes necessary for embryogenesis require a gene regulatory network
that is complex and systematic. Gene expression regulates development and …

How developmental gene expression is activated, co-ordinated and maintained is one of the
biggest questions in developmental biology. While transcription factors lead the way in …

The generation of complex organisms requires that an initial population of cells with
identical gene expression profiles can adopt different cell fates during development by …

Embryo development proceeds from a cascade of gene activation and repression events
controlled by epigenetic modifications of DNA and histones. Little is known about epigenetic …

Complex multi-cellular organisms are shaped starting from a single-celled zygote, owing to
elaborate developmental programs. These programs involve several layers of regulation to …

A hallmark of anamniote vertebrate development is a window of embryonic transcription-
independent cell divisions before onset of zygotic genome activation (ZGA). Chromatin …

Background Cell fate decisions are governed by interactions between sequence‐specific
transcription factors and a dynamic chromatin landscape. Zebrafish offer a powerful system …

Chromatin immunoprecipitation (ChIP) is arguably the assay of choice to determine the
genomic localization of DNA-or chromatin-binding proteins, including post-translationally …

An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs
essential for cellular function. The genome also harbors cis-acting non-coding sequences …