Histone modifications play a major role in the control of genes in their natural chromatin
context. A detailed, time-resolved analysis of histone modifications during gene activation …

We have generated transgenic zebrafish lines expressing a fusion of a histone variant, H2A.
F/Z, to the green fluorescent protein (GFP) of the jellyfish Aequorea victoria. Here, we …

Each cell within a multicellular organism has distinguishable characteristics established by
its unique patterns of gene expression. This individual identity is determined by the …

Epigenetic modifications of nucleosomal histones are thought to mediate transcriptional
states and impose heritable instructions upon differentiation. In a paper of Torres-Padilla …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

Epigenetic inheritance is a key element in the adaptation of organisms to a rapidly changing
environment without stably changing their DNA sequence. The necessary changes in its …

Accurate transcriptional control of genes is fundamental for the correct functioning of organs
and developmental processes. This control depends on the interplay between the promoter …

The early embryos of many animals, including flies, fish and frogs, have unusually rapid cell
cycles and delayed onset of transcription. These divisions are dependent on maternally …

Transcriptional regulatory elements are typically found in relatively nucleosome-free
genomic regions, often referred to as “open chromatin.” Deoxyribonuclease I (DNase I) can …

Advances in multiple disciplines such as genetics, molecular biology, and organismal
biology have highlighted the importance of epigenetic marks in gene regulation …