Phenolic acids represent a large collection of phytochemical molecules present in the plant
kingdom; they have an important role as epigenetic regulators, particularly as inhibitors of …

The liver possesses extraordinary regenerative capacity mainly attributable to the ability of
hepatocytes (HCs) and biliary epithelial cells (BECs) to self-replicate. This ability is left over …

The DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most
successful epigenetic drugs to date and are still the most widely used as epigenetic …

The cancer mortality rate of hepatocellular carcinoma (HCC) is the second highest in the
world and the therapeutic options are limited. The incidence of this deadly cancer is rising at …

DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The
first of these compounds (5-azacytidine, Vidaza) has recently been approved as an …

Aberrant DNA hypermethylation of promoter of tumor suppressor genes is commonly
observed in cancer, and its inhibition by small molecules is promising for their reactivation …

More questions than answers about the potential anticancer a... : Chinese Medical Journal
More questions than answers about the potential anticancer agents: DNA methylation inhibitors …

Both, DNA methylation and histone deacetylation play a crucial role in cancer development
by silencing the expression of specific tumour suppressor genes. Several studies describe …

The alteration of the DNA methylation pattern is often related to the onset of diseases based
on epigenetic dysregulation, primarily cancer. In this scenery the development of DNA …

DNA methylation is a critical component of gene regulation and plays an important role in
the development of cancer. Hypermethylation of tumor suppressor genes and silencing of …