Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
T Pfaffeneder, F Spada, M Wagner… - Nature chemical …, 2014 - nature.com
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells
Dioxygenases of the Ten-Eleven Translocation (TET) family are 5-methylcytosine oxidases
that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further …
that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further …
Tet-mediated formation of 5-hydroxymethylcytosine in RNA
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes
has been demonstrated to play a significant role in epigenetic regulation in mammals. We …
has been demonstrated to play a significant role in epigenetic regulation in mammals. We …
Charting oxidized methylcytosines at base resolution
DNA cytosine methylation is a key epigenetic mark that is required for normal mammalian
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA …
Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine
MY Liu, H Torabifard, DJ Crawford, JE DeNizio… - Nature chemical …, 2017 - nature.com
Ten-eleven translocation (TET) enzymes catalyze stepwise oxidation of 5-methylcytosine
(mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and …
(mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and …
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
5-Methylcytosine can be converted to 5-hydroxymethylcytosine (5hmC) in mammalian DNA
by the ten-eleven translocation (TET) enzymes. We introduce oxidative bisulfite sequencing …
by the ten-eleven translocation (TET) enzymes. We introduce oxidative bisulfite sequencing …
TET methylcytosine oxidases: new insights from a decade of research
In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to
the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has …
the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has …
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-
methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by …
methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by …
[HTML][HTML] Single-base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals promoter DNA methylation dynamics
Ten eleven translocation (Tet) proteins oxidize 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC …
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC …
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic
imprinting, and suppression of transposable elements. 5mC can be converted to 5 …
imprinting, and suppression of transposable elements. 5mC can be converted to 5 …