Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

Folic acid plays an important role in neuroplasticity and in the maintenance of neuronal
integrity. Folate is a co-factor in one-carbon metabolism during which it promotes the …

Clinical studies suggest a relationship between folate deficiency and neurological and
disorders including Alzheimer's disease (AD). To investigate mechanisms underlying this …

It has been known for decades that babies born to women that have a dietary deficiency in
folic acid (folate) are at increased risk for birth defects, and that the nervous system is …

Folate deficiency and resultant increased homocysteine levels have been linked
experimentally and epidemiologically with neurodegenerative conditions like stroke and …

Despite the key role in neuronal development of a deficit in the methyl donor folate, little is
known on the underlying mechanisms. We therefore studied the consequences of folate …

Epigenetic mechanisms underlying nutrition (nutrition epigenetics) are important in
understanding human health. Nutritional supplements, for example folic acid, a cofactor in …

Folate deficiency has been associated with age-related neurodegeneration. One direct
consequence of folate deficiency is a decline in the major methyl donor, S-adenosyl …

The vitamin folic acid has been recognized as a crucial environmental factor for nervous
system development. From the early fetal stages of the formation of the presumptive spinal …

In almost all tissues, including the brain, folates are required for one-carbon transfer
reactions, which are essential for the synthesis of DNA and RNA nucleotides, the …