Summary METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …

Abstract N6‐methyladenosine (m6A) methylation is the most prevalent RNA modification,
and it emerges as an important regulatory mechanism of gene expression involved in many …

Protein arginine methylation is a common post-translational modification in eukaryotes that
is catalyzed by a family of the protein arginine methyltransferases (PRMTs). PRMTs are …

In mammals, germ cells undergo massive epigenetic remodeling during fetal development.
However, the physiological functions of epigenetic modification in germ cell development …

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to
specific arginine residues of histones and nonhistone proteins. There are nine members in …

Background Covalent histone modifications are central to all DNA-dependent processes.
Modifications of histones H3 and H4 are becoming well characterised, but knowledge of …

Protein arginine methyltransferase 5 (PRMT5) is implicated in various types of human
cancer and tumor development, especially in lung cancer. Nevertheless, it is still unclear …

Abstract Protein arginine methyltransferase 1 (PRMT1) and the product of this enzyme
(histone H4 asymmetrically dimethylated at Arg 3; H4R3me2a) are important in the …

Histone arginine residue methylation is crucial for individual development and gene
regulation. However, the dynamics of histone arginine methylation in response to cellular …

PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional
regulation, DNA repair, and human immunodeficiency virus pathogenesis. Only few …